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KMID : 0604520230490010047
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 1 p.47 ~ p.58
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Effect of Skin Wrinkle Reduction Using Emulsions with Microbiome Extracts Selected by 3D Human Skin Equivalents
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Lim Jun-Woo
Kim Ye-Rim
Jeong Ji-Min
Jo Seong-Hyun
Jang Jin-Dong
Park Jun-Su
Kim Yun-Gon
Jeong Jae-Hyun
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Abstract
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Recently, along with the remarkable increase in interest in microbiome cosmetics, the application of microbiome extracts in the complex efficacy as anti-aging, brightening etc. has become very important. In this study, Bifidobacterium bifidum (B. bifidum), which has excellent anti-wrinkle efficacy among the microbiome, was selected through an in vitro test using cells and 3D human skin equivalents. And the anti-wrinkle efficacy of cosmetics containing B. bifidum was evaluated by clinical test. Thereafter, the cytotoxicity, anti-oxidation, anti-inflammatory and anti-wrinkle efficacy of the of the bifida fermented filtrate were tested. An emulsion containing bifida fermented filtrate at a concentration of 5% (v/v) with no cytotoxicity and excellent efficacy was prepared with the placebo emulsion. The clinical test was conducted on a total of 21 women at 2 weeks comparing the bifida emulsion and placebo emulsion. Wrinkles around the eyes were instrumentally evaluated using Antera 3D. The wrinkle reduction rate of the Bifida emulsion group compared with the placebo emulsion group differed by 5.6%. Overall, the selection of microbiome using 3D human skin equivalents and the efficacy study of cosmetics with the microbiome extracts would be actively studied to the development of microbiome cosmetics and skin microbiome mechanisms.
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KEYWORD
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microbiome, Bifidobacterium bifidum, 3D human skin equivalents, emulsion, skin wrinkle
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